Candene

PRODUCT HIGHLIGHTS

  • Patented anti-candidal herbal formulation for management of candidiasis
  • Unique mechanism of action
  • In vivo results comparable to that of gold standard (topical antifungal drug)
  • Intended to manage oral and vaginal candidiasis
  • Proven in silico, in vitro and in vivo efficacy

dosage forms

  • Oral gel
  • Mouth wash
  • Vaginal gel
  • Vaginal wash

In vivo Efficacy Study in animal model for candidiasis

  • Animals: BALB/c mice immuno compromised and infected with C. albicans
  • Comparator: Clotrimazole (2% gel)
  • Dose: 500 mg gel/mice twice daily in oral regions

In vivo efficacy results showing reduction of oral candidiasis lesion, comparable to that of clotrimazole, in tongue of BALB/c mice upon oral gel treatment

Mechanism of Action

  • Inhibits Candida sp. virulent enzymes: proteases and phospolipases
  • Inhibits Candida sp. constitutive enzymes: Aspartate semi-aldehyde dehydrogenase, lumazine synthase and  N-Myristoyil transferase
  • Inhibits germ tube formation

1. Inhibition of C. albicans Virulent Enzymes

Inhibition of protease and phospholipase of C. albicans upon Candene treatment.

2. Inhibition of Constituitive Enzyme

Native gel electrophoresis showing inhibition of protease of C. albicans upon Candene treatment.

3. Germ Tube Inhibitory Activity

Candida Germ Tube Inhibition of germ tube formation (indicated by arrow in control) upon treatment.

‘These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.’